Bowes, MA, Maciewicz, RA, Waterton, JC et al. (2 more authors) (2016) Bone area provides a responsive outcome measure for bone changes in short-term knee osteoarthritis studies. Journal of Rheumatology, 43 (12). pp. 2179-2182. ISSN 0315-162X
Abstract
Objective: This post-hoc study analyzed 3D bone area from an osteoarthritis (OA) cohort demonstrating no change in cartilage thickness. Methods: 27 women with painful medial knee OA had MRI at 0, 3 and 6 months. Images were analysed using active appearance models. Results: At 3 and 6 months the mean change in medial femoral bone area was 0.34% [95% CI 0.04, 0.64] and 0.61% [CI 0.32, 0.90]. 40% of subjects had progression > SDD at 6 months. Conclusion: In this small cohort at high risk of OA progression, bone area changed at 3 and 6 months when cartilage morphometric measures did not.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016. This is an author produced version of a paper published in Journal of Rheumatology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bone; Knee; Osteoarthritis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 Aug 2016 09:10 |
Last Modified: | 01 Dec 2017 01:38 |
Published Version: | https://doi.org/10.3899/jrheum.151118 |
Status: | Published |
Publisher: | Journal of Rheumatology |
Identification Number: | 10.3899/jrheum.151118 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:103446 |