Rawson, S, Davies, S, Lippiat, JD orcid.org/0000-0003-3748-7345 et al. (1 more author) (2016) The changing landscape of membrane protein structural biology through developments in electron microscopy. Molecular Membrane Biology, 33 (1-2). pp. 12-22. ISSN 0968-7688
Abstract
Membrane proteins are ubiquitous in biology and are key targets for therapeutic development. Despite this, our structural understanding has lagged behind that of their soluble counterparts. This review provides an overview of this important field, focusing in particular on the recent resurgence of electron microscopy (EM) and the increasing role it has to play in the structural studies of membrane proteins, and illustrating this through several case studies. In addition we examine some of the challenges remaining in structural determination, and what steps are underway to enhance our knowledge of these enigmatic proteins.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Electron Microscopy; Membrane Protein; Protein Structure |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Funding Information: | Funder Grant number MRC G1000567/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Aug 2016 13:34 |
Last Modified: | 17 Jan 2018 08:08 |
Published Version: | http://dx.doi.org/10.1080/09687688.2016.1221533 |
Status: | Published |
Publisher: | Taylor & Francis |
Identification Number: | 10.1080/09687688.2016.1221533 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:103415 |