Alhilou, A, Do, T orcid.org/0000-0002-5668-2181, Mizban, L et al. (3 more authors) (2016) Physicochemical and Antibacterial Characterisation of a Novel Fluorapatite Coating. ACS Omega, 1 (2). pp. 264-276.
Abstract
Peri-implantitis remains the major impediment to the long-term use of dental
implants. With increasing concern over growing antibiotic resistance there is
considerable interest in the preparation of antimicrobial dental implant coatings that
also induce osseointegration. One such potential coating material is fluorapatite
(FA). The aim of this study was to relate the antibacterial effectiveness of FA
coatings against pathogens implicated in peri-implantitis to the physicochemical
properties of the coating. Ordered and disordered FA coatings were produced on the
under and upper surface of stainless steel (SS) discs respectively, using a
hydrothermal method. Surface charge, surface roughness, wettability and fluoride
release were measured for each coating. Surface chemistry was assessed by X-ray
photoelectron spectroscopy and FA crystallinity by X-ray diffraction. Antibacterial
activity against periodontopathogens was assessed in vitro using viable counts,
confocal and scanning electron (SEM) microscopies. SEM showed that the
hydrothermal method produced FA coatings predominately aligned perpendicular to
the SS substrate or disordered FA coatings consisting of randomly aligned rod-like
crystals. Both FA coatings significantly reduced the growth of all the examined
bacterial strains in comparison to the control. The FA coatings, and especially the
disordered ones, presented significantly lower charge, higher roughness and area
when compared to the control, enhancing bacteria–material interactions and
therefore bacterial deactivation by fluoride ions. The ordered FA layer reduced not
only bacterial viability but adhesion too. Ordered FA crystals produced as a potential
novel implant coating showed significant antibacterial activity against bacteria
implicated in peri-implantitis which could be explained by a detailed understanding of
their physicochemical properties.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
Keywords: | Dental implants, fluorapatite, coatings, peri-implantitis, antibacterial, surface characterisation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 Aug 2016 15:04 |
Last Modified: | 25 Apr 2019 13:55 |
Published Version: | https://dx.doi.org/10.1021/acsomega.6b00080 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/acsomega.6b00080 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:103397 |