Hunt, Andrew John orcid.org/0000-0003-3983-8313, Farmer, Thomas James orcid.org/0000-0002-1039-7684, Sherwood, James Richard orcid.org/0000-0001-5431-2032 et al. (2 more authors) (2016) N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis. Green Chemistry. pp. 3990-3996. ISSN 1463-9262
Abstract
Dipolar aprotic solvents such as N-methylpyrrolidinone (or 1-methyl-2-pyrrolidone (NMP)) are under increasing pressure from environmental regulation. NMP is a known reproductive toxin and has been placed on the EU “Substances of Very High Concern” list. Accordingly there is an urgent need for non-toxic alternatives to the dipolar aprotic solvents. N-Butylpyrrolidinone, although structurally similar to NMP, is not mutagenic or reprotoxic, yet retains many of the characteristics of a dipolar aprotic solvent. This work introduces N-butylpyrrolidinone as a new solvent for cross-coupling reactions and other syntheses typically requiring a conventional dipolar aprotic solvent.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 28 Jul 2016 10:07 |
Last Modified: | 16 Oct 2024 13:10 |
Published Version: | https://doi.org/10.1039/C6GC00932H |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/C6GC00932H |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:103040 |
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