Randall, CP orcid.org/0000-0002-9565-8387, Rasina, D, Jirgensons, A et al. (1 more author) (2016) Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme. Antimicrobial Agents and Chemotherapy, 60 (10). pp. 6359-6361. ISSN 0066-4804
Abstract
Bacterial aminoacyl-tRNA synthetases (aaRSs) represent promising antibacterial drug targets. Unfortunately, the aaRS inhibitors that have to date reached clinical trials are subject to rapid resistance development through mutation, a phenomenon that limits their potential clinical utility. Here, we confirm the intuitively correct idea that simultaneous targeting of two different aaRS enzymes prevents the emergence of spontaneous bacterial resistance at high frequency, a finding that supports the development of multitargeted anti-aaRS therapies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016, American Society for Microbiology. This is an author produced version of a paper published in Antimicrobial agents and chemotherapy. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) |
Funding Information: | Funder Grant number EU - European Union 601725 |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Jul 2016 11:00 |
Last Modified: | 19 Jan 2017 15:48 |
Published Version: | http://dx.doi.org/10.1128/AAC.00674-16 |
Status: | Published |
Publisher: | American Society for Microbiology |
Identification Number: | 10.1128/AAC.00674-16 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:102777 |