Firth, JD, Craven, PGE, Lilburn, M et al. (3 more authors) (2016) A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds. Chemical Communications, 52 (63). pp. 9837-9840. ISSN 1359-7345
Abstract
A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © 2016, The Royal Society of Chemistry 2016. Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Jul 2016 15:40 |
Last Modified: | 29 Dec 2019 13:47 |
Published Version: | http://dx.doi.org/10.1039/c6cc04662b |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/C6CC04662B |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:102489 |