Warriner, D.R., Lawford, P. and Sheridan, P.J. (2016) Cardiac Resynchronization Therapy Leads to Improvements in Handgrip Strength. Cardiology Research, 7 (3). pp. 95-103. ISSN 1923-2829
Abstract
Background: A reduction in skeletal muscle performance measured by handgrip strength is common in heart failure. No trial has investigated the role of cardiac resynchronization therapy, which leads to improvements in cardiac performance, on the function of skeletal muscle in patients with heart failure. Methods: Nineteen patients were recruited, 18 male, age 69 ± 8 years, New York Heart Association class II-IV, QRS duration 173 ± 21 ms and left ventricular ejection fraction 26±8%. Handgrip strength was measured at baseline before, and 6 and 12 months, following cardiac resynchronization therapy. Response was assessed using quality of life questionnaire, 6-minute walk distance, left ventricular enddiastolic volume, and cardiopulmonary exercise testing at the same time points. Results: Fourteen patients were identified as responders, demonstrating significant improvements in all four markers of response. There was no significant difference at baseline in left or right handgrip strength between responders and non-responders. Compared to baseline, handgrip strength significantly increased in responders during follow-up, left (34.4 ± 11.4 to 40.3 ± 11.3 kgf, P < 0.001) and right (35.7 ± 12.5 to 42.2 ± 11.5 kgf, P < 0.001) at 12 months. No such improvement was seen in non-responders. Conclusions: This study demonstrates that positive response to cardiac resynchronization therapy is associated with significant gains in handgrip strength, suggesting that cardiac resynchronization therapy may indirectly lead to secondary gains in skeletal muscle function.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Authors 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Cardiology Research is published by Elmer Press Inc. |
Keywords: | Cardiac resynchronization therapy; Heart failure; Handgrip strength |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 Jul 2016 08:55 |
Last Modified: | 01 Nov 2018 11:52 |
Published Version: | http://dx.doi.org/10.14740/cr475w |
Status: | Published |
Publisher: | Elmer Press |
Refereed: | Yes |
Identification Number: | 10.14740/cr475w |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:102363 |