Wilcock, C.J., Stafford, G.P., Miller, C.A. orcid.org/0000-0002-6062-6254 et al. (5 more authors) (2017) Preparation and Antibacterial Properties of Silver-doped Nanoscale Hydroxyapatite Pastes for Bone Repair and Augmentation. Journal of Biomedical Nanotechnology, 13 (9). pp. 1168-1176. ISSN 1550-7041
Abstract
The treatment of deep bone infections remains a significant challenge in orthopaedic and dental surgery. The relatively recent commercial manufacture of nanoscale hydroxyapatite has provided surgeons with an injectable biomaterial that promotes bone tissue regeneration, and with further modification it may be possible to incorporate antimicrobial properties into these devices. Silver-doped nanoscale hydroxyapatite pastes (0, 2, 5 and 10 mol. % silver) were prepared using a rapid mixing method. When the process was modified to prepare a 10 mol. % silver-doped material, silver phosphate was detected in addition to nanoscale hydroxyapatite. Thermal decomposition occurred more readily with greater silver content following calcination at 1000 °C for 2 h. Silver-doped nanoscale hydroxyapatite pastes showed antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa in a dose dependent manner using both agar diffusion assays and suspension cultures. It was concluded that the enhanced antibacterial activity of the silver-doped pastes was due to the action of diffusible silver ions. Based on these results, silver-doped nanoscale hydroxyapatite pastes represent a highly promising new biomaterial system for the prevention and treatment of deep infections in bone tissue.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 American Scientific Publishers |
Keywords: | Nanoscale Hydroxyapatite; Antibacterial; Biomaterial Characterisation; Silver; Injectable; Antimicrobial; Bone tissue repair; Bone infection; Osteoconductive; Biomimetic |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/K029592/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 Jul 2016 10:57 |
Last Modified: | 29 Jan 2020 13:27 |
Published Version: | https://doi.org/10.1166/jbn.2017.2387 |
Status: | Published |
Publisher: | American Scientific Publishers |
Refereed: | Yes |
Identification Number: | 10.1166/jbn.2017.2387 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:102317 |