De Felice, M. and Ossipov, M.H. (2016) Cortical and subcortical modulation of pain. Pain Management, 6 (2). pp. 111-120. ISSN 1758-1869
Abstract
Pain is more than merely nociception and response, but rather it encompasses emotional, behavioral and cognitive components that make up the pain experience. With the recent advances in imaging techniques, we now understand that nociceptive inputs can result in the activation of complex interactions among central sites, including cortical regions that are active in cognitive, emotional and reward functions. These sites can have a bimodal influence on the serotonergic and noradrenergic descending pain modulatory systems via communications among the periaqueductal gray, rostral ventromedial medulla and pontine noradrenergic nuclei, ultimately either facilitating or inhibiting further nociceptive inputs. Understanding these systems can help explain the emotional and cognitive influences on pain perception and placebo/nocebo effects, and can help guide development of better pain therapeutics.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Future Medicine |
Keywords: | PAG; RVM; descending modulation; endogenous opioid; gabapentin; neuropathic pain; nociception; noradrenergic pain modulation; noradrenergic projections; pain matrix; serotonergic pain modulation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 17 Aug 2016 08:49 |
Last Modified: | 03 Nov 2016 02:25 |
Published Version: | http://dx.doi.org/10.2217/pmt.15.63 |
Status: | Published |
Publisher: | Future Medicine |
Refereed: | Yes |
Identification Number: | 10.2217/pmt.15.63 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:102298 |