Walsh, E, Rees, CJ, Gill, M et al. (8 more authors) (2016) Are there biological differences between screen-detected and interval colorectal cancers in the English Bowel Cancer Screening Programme? British Journal of Cancer, 115 (2). pp. 261-265. ISSN 0007-0920
Abstract
Background: We measured biomarkers of tumour growth and vascularity in interval and screen-detected colorectal cancers (CRCs) in the English Bowel Cancer Screening Programme in order to determine whether rapid tumour growth might contribute to interval CRC (a CRC diagnosed between a negative guaiac stool test and the next scheduled screening episode). Methods: Formalin-fixed, paraffin-embedded sections from 71 CRCs (screen-detected 43, interval 28) underwent immunohistochemistry for CD31 and Ki-67, in order to measure the microvessel density (MVD) and proliferation index (PI), respectively, as well as microsatellite instability (MSI) testing. Results: Interval CRCs were larger (P=0.02) and were more likely to exhibit venous invasion (P=0.005) than screen-detected tumours. There was no significant difference in MVD or PI between interval and screen-detected CRCs. More interval CRCs displayed MSI-high (14%) compared with screen-detected tumours (5%). A significantly (P=0.005) higher proportion (51%) of screen-detected CRC resection specimens contained at least one polyp compared with interval CRC (18%) resections. Conclusions: We found no evidence of biological differences between interval and screen-detected CRCs, consistent with the low sensitivity of guaiac stool testing as the main driver of interval CRC. The contribution of synchronous adenomas to occult blood loss for screening requires further investigation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016, Cancer Research UK. This version is made available under the Creative Commons Attribution Non-Commercial Share Alike license CC BY-NC-SA 4.0 https://creativecommons.org/licenses/by-nc-sa/4.0/ |
Keywords: | angiogenesis; colorectal cancer; faecal occult blood test; proliferation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Funding Information: | Funder Grant number South Tyneside NHS Foundation Trust STFT 016/2013 |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Jul 2016 10:57 |
Last Modified: | 07 Aug 2017 17:51 |
Published Version: | https://doi.org/10.1038/bjc.2016.159 |
Status: | Published |
Publisher: | Cancer Research UK |
Identification Number: | 10.1038/bjc.2016.159 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:101972 |