Rao, M., Stewart, N.J., Norquay, G. et al. (2 more authors) (2016) High resolution spectroscopy and chemical shift imaging of hyperpolarized 129 Xe dissolved in the human brain in vivo at 1.5 tesla. Magnetic Resonance in Medicine, 75 (6). pp. 2227-2234. ISSN 0740-3194
Abstract
Purpose Upon inhalation, xenon diffuses into the bloodstream and is transported to the brain, where it dissolves in various compartments of the brain. Although up to five chemically distinct peaks have been previously observed in 129Xe rat head spectra, to date only three peaks have been reported in the human head. This study demonstrates high resolution spectroscopy and chemical shift imaging (CSI) of 129Xe dissolved in the human head at 1.5 Tesla.
Methods A 129Xe radiofrequency coil was built in-house and 129Xe gas was polarized using spin-exchange optical pumping. Following the inhalation of 129Xe gas, NMR spectroscopy was performed with spectral resolution of 0.033 ppm. Two-dimensional CSI in all three anatomical planes was performed with spectral resolution of 2.1 ppm and voxel size 20 mm × 20 mm.
Results Spectra of hyperpolarized 129Xe dissolved in the human head showed five distinct peaks at 188 ppm, 192 ppm, 196 ppm, 200 ppm, and 217 ppm. Assignment of these peaks was consistent with earlier studies.
Conclusion High resolution spectroscopy and CSI of hyperpolarized 129Xe dissolved in the human head has been demonstrated. For the first time, five distinct NMR peaks have been observed in 129Xe spectra from the human head in vivo.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | hyperpolarized gas; xenon spectroscopy; chemical shift imaging; human brain spectroscopy |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/D070252/1 NATIONAL INSTITUTE FOR HEALTH RESEARCH NIHR-RP-R3-12-027 MEDICAL RESEARCH COUNCIL MR/M008894/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 Jul 2016 13:45 |
Last Modified: | 14 Jul 2016 13:45 |
Published Version: | http://dx.doi.org/10.1002/mrm.26241 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/mrm.26241 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:101639 |
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