El-Jawhari, JJ, Jones, E, McGonagle, D et al. (1 more author) (2016) Interactions between multipotential stromal cells (MSCs) and immune cells during bone healing. In: Abdelalim, EM, (ed.) Recent Advances in Stem Cells: From Basic Research to Clinical Applications. Stem Cell Biology and Regenerative Medicine . Springer (Humana Press) ISBN 978-3-319-33268-0
Abstract
The physiological process of bone healing takes place in three sequential stages: inflammation, repair and remodelling. Multipotential stromal cells (MSCs) are the key progenitor cells for osteoblasts and chondrocytes and are also imbued with immunomodulatory capabilities. Although MSCs are well known to be involved in osteogenesis during the later stages of repair, their role during the inflammatory phase and precise interactions with immune cells remain poorly understood. This chapter describes the current knowledge on cellular interactions during the bone repair as well as cytokines and growth factors mediating these processes. The roles of emerging innate immune cell populations, innate lymphoid cells are also discussed. Based on this current knowledge, we conclude that in addition to their differentiation during later bone repair stages, MSCs are likely to have a substantial involvement in the initial stage of bone healing by controlling the fate of inflammation. An improved understanding of complex cell interactions during bone repair has broad implications on optimising the treatment of the fracture complications including non-union.
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © 2016, Springer International Publishing Switzerland. This is an author produced version of a paper published in Recent Advances in Stem Cells, ed. Essam M. Abdelalim. Uploaded in accordance with the publisher's self-archiving policy. The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-33270-3 |
Keywords: | Bone repair, MSCs, immune cells, bone fracture |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Experimental Musculoskeletal Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Jun 2016 13:25 |
Last Modified: | 25 Jul 2017 16:10 |
Status: | Published |
Publisher: | Springer (Humana Press) |
Series Name: | Stem Cell Biology and Regenerative Medicine |
Identification Number: | 10.1007/978-3-319-33270-3 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:101369 |