O'Brien, D and Van Oosten-Hawle, PC orcid.org/0000-0002-5713-6457 (2016) Regulation of cell-nonautonomous proteostasis in metazoans. Essays in Biochemistry, 60 (2). pp. 133-142. ISSN 0071-1365
Abstract
Cells have developed robust adaptation mechanisms to survive environmental conditions that challenge the integrity of their proteome and ensure cellular viability. These are stress-signalling pathways that integrate extracellular signals with the ability to detect and efficiently respond to protein-folding perturbations within the cell. Within the context of an organism, the cell autonomous effects of these signalling mechanisms are superimposed by cell-nonautonomous stress signalling pathways that allow coordination of stress responses across tissues. These transcellular stress signalling pathways orchestrate and maintain the cellular proteome at an organismal level. This review focuses on mechanisms in both invertebrate and vertebrate organisms that activate stress responses in a cell-nonautonomous manner. We discuss emerging insights and provide specific examples on how components of the cell-nonautonomous proteostasis network are used in cancer and protein-folding diseases to drive disease progression across tissues.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2016 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY). |
Keywords: | cancer; cell-non-autonomous; heat-shock response; protein-misfolding diseases; proteostasis; stress responses; systemic proteostasis; transcellular chaperone signalling; unfolded protein response |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
Funding Information: | Funder Grant number Royal Society RG140581 Wellcome Trust 200698/Z/16/Z |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Jun 2016 14:08 |
Last Modified: | 05 Oct 2017 16:19 |
Published Version: | https://doi.org/10.1042/EBC20160006 |
Status: | Published |
Publisher: | Portland Press |
Identification Number: | 10.1042/EBC20160006 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:101347 |