Vickers, RJ, Tillotson, G, Goldstein, EJC et al. (3 more authors) (2016) Ridinilazole: A novel therapy for Clostridium difficile infection. International Journal of Antimicrobial Agents, 48 (2). pp. 137-143. ISSN 0924-8579
Abstract
Clostridium difficile infection (CDI) is the leading cause of infectious healthcare-associated diarrhoea. Recurrent CDI increases disease morbidity and mortality, posing a high burden to patients and a growing economic burden to the healthcare system. Thus, there exists a significant unmet and increasing medical need for new therapies for CDI. This review aims to provide a concise summary of CDI in general and a specific update on ridinilazole (formerly SMT19969), a novel antibacterial currently under development for the treatment of CDI. Owing to its highly targeted spectrum of activity and ability to spare the normal gut microbiota, ridinilazole provides significant advantages over metronidazole and vancomycin, the mainstay antibiotics for CDI. Ridinilazole is bactericidal against . C. difficile and exhibits a prolonged post-antibiotic effect. Furthermore, treatment with ridinilazole results in decreased toxin production. A phase 1 trial demonstrated that oral ridinilazole is well tolerated and specifically targets clostridia whilst sparing other faecal bacteria. Phase 2 and 3 trials will hopefully further our understanding of the clinical utility of ridinilazole for the treatment of CDI.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Ridinilazole; SMT19969; Clostridium difficile infection; Antibacterial therapy; Gut microbiota |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Oct 2016 11:50 |
Last Modified: | 18 Jan 2023 16:55 |
Published Version: | http://dx.doi.org/10.1016/j.ijantimicag.2016.04.02... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ijantimicag.2016.04.026 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:101299 |