Vilozny, B, Wollenberg, AL, Actis, P orcid.org/0000-0002-7146-1854 et al. (3 more authors) (2013) Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette. Nanoscale, 5 (19). pp. 9214-9221. ISSN 2040-3364
Abstract
Nanofluidic structures share many properties with ligand-gated ion channels. However, actuating ion conductance in artificial systems is a challenge. We have designed a system that uses a carbohydrate-responsive polymer to modulate ion conductance in a quartz nanopipette. The cationic polymer, a poly(vinylpyridine) quaternized with benzylboronic acid groups, undergoes a transition from swollen to collapsed upon binding to monosaccharides. As a result, the current rectification in nanopipettes can be reversibly switched depending on the concentration of monosaccharides. Such molecular actuation of nanofluidic conductance may be used in novel sensors and drug delivery systems.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) > Pollard Institute (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Sep 2017 13:59 |
Last Modified: | 07 Sep 2017 13:59 |
Published Version: | https://dx.doi.org/10.1039/c3nr02105j |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/c3nr02105j |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:101080 |