Al-Khazrajy, Omar S A and Boxall, Alistair B A orcid.org/0000-0003-3823-7516 (2016) Impacts of compound properties and sediment characteristics on the sorption behaviour of pharmaceuticals in aquatic systems. Journal of hazardous materials. pp. 198-209. ISSN 0304-3894
Abstract
Sorption is a key factor in determining the persistence, attenuation and bioavailability of sediment-associated contaminants. However, our understanding of the sorption behaviour of pharmaceuticals in sediments is poor. In this study, we investigated the sorption behaviour of a diverse set of pharmaceuticals in a range sediment types. Sorption affinity of pharmaceuticals for all sediments was found to increase in the order mefenamic acid <cimetidine <atenolol <amitriptyline <diltiazem. Comparison of the experimental observations with predictions from an existing model for estimating sorption revealed the model worked poorly for the study pharmaceuticals. Multiple linear regression analysis was therefore used to develop new models for estimating sorption of individual pharmaceuticals based on sediment properties. The analyses indicated that sorption is related to properties such as Log Dow of a compound in the sediment (lipophilicity corrected for the sediment pH), cation exchange capacity, clay%, organic carbon content and exchangeable Ca2+, although, with the exception of atenolol, robust relationships between sediment properties and sorption were not obtained. Overall, the results demonstrate how complex the processes are that drive the sorption of pharmaceuticals in sediments and highlight the need for generation of further experimental data and further model development work.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Elsevier B.V. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Distribution coefficient (Kd),Modelling,Pharmaceuticals,Sediment characteristics,Sorption isotherms |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Environment and Geography (York) |
Depositing User: | Pure (York) |
Date Deposited: | 16 Jun 2016 15:24 |
Last Modified: | 16 Oct 2024 13:06 |
Published Version: | https://doi.org/10.1016/j.jhazmat.2016.05.065 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.jhazmat.2016.05.065 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:101069 |
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Filename: Pharmaceutical_sorption_in_sediment.pdf
Description: Pharmaceutical sorption in sediment
Licence: CC-BY-NC-ND 2.5