Salmond, RJ, Brownlie, RJ and Zamoyska, R (2015) Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 inregulating T cell homeostasis. Cell Cycle, 14 (5). pp. 705-711. ISSN 1538-4101
Abstract
The non-receptor tyrosine phosphatase PTPN22 has a vital function in inhibiting antigen-receptor signaling in T cells, while polymorphisms in the PTPN22 gene are important risk alleles in human autoimmune diseases. We recently reported that a key physiological function of PTPN22 was to prevent naïve T cell activation and effector cell responses in response to low affinity antigens. PTPN22 also has a more general role in limiting T cell receptor-induced proliferation. Here we present new data emphasizing this dual function for PTPN22 in T cells. Furthermore, we show that T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases. We discuss the implication of these findings for our understanding of the roles of PTPN22 in regulating T cell responses and in autoimmunity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
Keywords: | autoimmunity; phosphatase; PTPN22; signal transduction; T cell |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Oncology and Cancer Research - Labs (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Aug 2016 15:08 |
Last Modified: | 04 Aug 2016 15:08 |
Published Version: | http://dx.doi.org/10.1080/15384101.2015.1007018 |
Status: | Published |
Publisher: | Taylor & Francis |
Identification Number: | 10.1080/15384101.2015.1007018 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:101007 |