Duckett, Simon orcid.org/0000-0002-9788-6615, Green, Gary George Reginald orcid.org/0000-0003-1977-7509, Olaru, Maria Alexandra orcid.org/0000-0002-2244-1048 et al. (3 more authors) (2016) Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE. Chemical Communications. ISSN 1364-548X
Abstract
The creation of magnetic states that have long lifetimes has been the subject of intense investigation, in part because of their potential to survive the time taken to travel from the point of injection in a patient to the point where a clinically diagnostic MRI trace is collected. We show here that it is possible to harness the Signal Amplification By Reversible Exchange (SABRE) process to create such states in a hyperpolarised form that improves their detectability in seconds without the need for any chemical change by reference to the model substrate 2-aminothiazole. We achieve this by transferring Zeeman derived polarisation that is 1500 times larger than that normally available at 400 MHz with greater than 90 % efficiency into the new state, which in this case has a 27 second lifetime.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | ©The Royal Society of Chemistry 2016. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Psychology (York) |
Funding Information: | Funder Grant number WELLCOME TRUST 098335/Z/12/Z |
Depositing User: | Pure (York) |
Date Deposited: | 13 Jun 2016 13:51 |
Last Modified: | 21 Jan 2025 17:21 |
Published Version: | https://doi.org/10.1039/C6CC02020H |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1039/C6CC02020H |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:100857 |