Purification of Nanoparticles by Size and Shape

Abstract

Producing monodisperse nanoparticles is essential to ensure consistency in biological experiments and to enable a smooth translation into the clinic. Purification of samples into discrete sizes and shapes may not only improve sample quality, but also provide us with the tools to understand which physical properties of nanoparticles are beneficial for a drug delivery vector. In this study, using polymersomes as a model system, we explore four techniques for purifying pre-formed nanoparticles into discrete fractions based on their size, shape or density. We show that these techniques can successfully separate polymersomes into monodisperse fractions.

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Item Type:	Article
Authors/Creators:	Robertson, J.D. Rizzello, L. Avila-Olias, M. Gaitzsch, J. Contini, C. Magoń, M.S. Renshaw, S.A. https://orcid.org/0000-0003-1790-1641 Battaglia, G.
Copyright, Publisher and Additional Information:	This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Dates:	Published: 8 June 2016 Published (online): 8 June 2016 Accepted: 18 May 2016
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection and Immunity (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals
Depositing User:	Symplectic Sheffield
Date Deposited:	15 Jun 2016 11:23
Last Modified:	15 Jun 2016 11:23
Published Version:	http://dx.doi.org/10.1038/srep27494
Status:	Published
Publisher:	Nature Publishing Group
Refereed:	Yes
Identification Number:	10.1038/srep27494
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:100847

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Purification of Nanoparticles by Size and Shape

Abstract

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Robertson et al, Sci Rep 2016

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