Selby, P, Patel, P, Milan, S et al. (7 more authors) (1990) ChlVPP combination chemotherapy for Hodgkin's disease: long-term results. British Journal of Cancer, 62 (2). pp. 279-285. ISSN 0007-0920
Abstract
Two hundred and eighty-four patients with advanced Hodgkin's disease (HD) (stage II with poor prognostic features and stage III/IV) have been treated with the ChlVPP combination chemotherapy regimen (chlorambucil, vinblastine, procarbazine and prednisolone) in a single-centre unselected series. Median follow up is 92 months. Fifty-five patients had previously received radiotherapy but none had received previous chemotherapy. Eighty-five per cent of previously untreated patients and 91% of previously irradiated patients entered complete remission (CR); 71% and 68% of these respectively remain in CR at 10 years and 65% and 64% of each group respectively are alive at 10 years. On univariate analysis, age, stage, site of visceral disease and lymphocyte count predicted survival and on multivariate analysis age, absence of symptoms, absence of lung, liver or bone marrow disease and achieving a CR remained important predictors of survival. Acute toxicity was mild. The 10 year actuarial risk of acute leukaemia was 2.7%. This study adds further support to the view that chlorambucil is as effective and less toxic than mustine in combination chemotherapy for HD. We suggest that MOPP chemotherapy is no longer routinely indicated for HD.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 1990, Macmillan Press. Reproduced in accordance with the publisher's self-archiving policy, under a Creative Commons Attribution Non-Commercial Share Alike License. |
Keywords: | Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Chlorambucil; Death; Female; Hodgkin Disease; Humans; Leukemia, Myeloid; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Prednisolone; Procarbazine; Vinblastine |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Clinical Cancer Research (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Jun 2016 13:39 |
Last Modified: | 21 Jun 2016 13:39 |
Published Version: | http://dx.doi.org/10.1038/bjc.1990.278 |
Status: | Published |
Publisher: | Cancer Research UK/Macmillan Press |
Identification Number: | 10.1038/bjc.1990.278 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:100584 |