Zulian, GB, Selby, P, Milan, S et al. (5 more authors) (1989) High dose melphalan, BCNU and etoposide with autologous bone marrow transplantation for Hodgkin’s disease. British Journal of Cancer, 59 (4). pp. 631-635. ISSN 0007-0920
Abstract
Thirty-eight patients with previously treated Hodgkin’s disease were given high dose combination chemotherapy using melphalan and BCNU and autologous bone marrow transplantation. In 25 patients etoposide was added in conventional dosage. During the course of the study the dose of melphalan was increased from 80 to 140 mg m−2and the dose of BCNU from 300 to 600 mg m−2. The response rate was 76% with 53% complete remission. Forty-five per cent of the patients are free of disease at 4–20 months follow-up. There were eight (26%) treatment-related deaths due to lung damage (seven cases) and irreversible cardiac failure (one case). Fatal lung damage occurred only in patients receiving 600 mg m−2of BCNU with high dose melphalan. The dose of BCNU given with high dose melphalan should not exceed 500 mg m−2. This treatment is effective against relapsed Hodgkin’s disease but must be used cautiously. The best time for its use remains to be determined.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 1989, The Macmillan Press Ltd. Reproduced in accordance with the publisher's self-archiving policy under a Creative Commons Attribution Non-Commercial Share Alike License |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Clinical Cancer Research (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Jun 2016 14:56 |
Last Modified: | 21 Jun 2016 14:56 |
Published Version: | http://dx.doi.org/10.1038/bjc.1989.128 |
Status: | Published |
Publisher: | Cancer Research UK/Macmillan Press |
Identification Number: | 10.1038/bjc.1989.128 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:100578 |