Cameron, DA, Anderson, A, Toy, E et al. (9 more authors) (2002) Block sequential adriamycin CMF – optimal non-myeloablative chemotherapy for high risk adjuvant breast cancer? British Journal of Cancer, 87 (12). pp. 1365-1369. ISSN 0007-0920
Abstract
After the publication of the 10-year survival data from Milan on the adjuvant use of the block sequential regimen consisting of four cycles of adriamycin followed by eight cycles of intravenous CMF, many centres adopted this as standard of care for high risk, multiple node-positive breast cancer. For this reason it was identified as the standard arm for the Anglo-Celtic adjuvant high-dose chemotherapy trial. This study reports on the experience of this regimen in 329 women with early breast cancer involving at least four axillary nodes, who were treated outside any adjuvant chemotherapy trial. At a median follow-up of 3 years, the overall 5-year disease-free survival is 61%, and the overall survival is 70%. These data confirm the efficacy of this regimen in non-trial patients, and, for the same high risk subgroup, indicate that this approach offers an outcome at least as good as that seen in the CALGB 9344 AC-Taxol arm, and the NCIC days 1 and 8 CEF.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2002 Cancer Research UK. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
Keywords: | anthracycline; adjuvant; breast cancer; survival |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Clinical Cancer Research (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Oncology and Clinical Research (Leeds) > National Institute for Health Research (Leeds) > NCRN (NIHR Cancer Research Network) (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > Medicine & Health Faculty Office (Leeds) > National Institute for Health Research (Leeds) > NCRN (NIHR Cancer Research Network) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Jul 2016 11:19 |
Last Modified: | 14 Jul 2016 11:19 |
Published Version: | http://dx.doi.org/10.1038/sj.bjc.6600660 |
Status: | Published |
Publisher: | Cancer Research UK |
Identification Number: | 10.1038/sj.bjc.6600660 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:100568 |