Horn, F.C., Rao, M., Stewart, N.J. et al. (1 more author) (2017) Multiple breath washout of hyperpolarized 129Xe and 3He in human lungs with 3D bSSFP imaging. Magnetic Resonance in Medicine, 77 (6). pp. 2288-2295. ISSN 0740-3194
Abstract
Purpose: (i) To compare quantitative fractional ventilation measurements from multiple breath washout imaging (MBW-I) using hyperpolarized (HP) 3He with both spoiled gradient echo (SPGR) and balanced steady-state free-precession (bSSFP) 3D pulse sequences and (ii) to evaluate the feasibility of MBW-I with HP 129Xe. Methods: Seven healthy volunteers were scanned using 3He MBW-I with 3D SPGR and bSSFP sequences. Five also underwent MBW-I with 129Xe. A dual-tuned coil was used to acquire MBW-I data from both nuclei in the same subject position, enabling direct comparison of regional information. Results: High-quality MBW images were obtained with bSSFP sequences using a reduced dose (100ml) of inhaled hyperpolarized 3He. 3D MBW-I with 129Xe was also successfully demonstrated with a bSSFP sequence. Regional quantitative ventilation measures derived from 3He and 129Xe MBW-I correlated well in all subjects (p<0.001) with mean Pearson’s correlation coefficients of r=0.61 and r=0.52 for 3He SPGR-bSSFP and 129Xe-3He (bSSFP) comparisons. The average inter-volunteer mean difference (and standard deviation) in fractional ventilation in SPGR-bSSFP and 129Xe-3He comparisons was 15% (28%) and 9% (38%), respectively. Conclusions: Improved sensitivity in MBW-I can be achieved with polarization-efficient bSSFP sequences. Same scan-session 3D MBW-I with 3He and 129Xe has been demonstrated using a dual-tuned coil.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Hyperpolarized gas; 129Xe; 3He; multiple breath washout; lung function |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection and Immunity (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 06 Jun 2016 10:04 |
Last Modified: | 18 Jul 2017 10:57 |
Published Version: | http://dx.doi.org/10.1002/mrm.26319 |
Status: | Published |
Publisher: | John Wiley & Sons |
Refereed: | Yes |
Identification Number: | 10.1002/mrm.26319 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:100351 |
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