Potter, GDM, Cade, JE orcid.org/0000-0003-3421-0121, Grant, PJ et al. (1 more author) (2016) Nutrition and the circadian system. British Journal of Nutrition, 116 (3). pp. 434-442. ISSN 0007-1145
Abstract
The human circadian system anticipates and adapts to daily environmental changes to optimise behaviour according to time of day and temporally partitions incompatible physiological processes. At the helm of this system is a master clock in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus. The SCN are primarily synchronised to the 24-h day by the light/dark cycle; however, feeding/fasting cycles are the primary time cues for clocks in peripheral tissues. Aligning feeding/fasting cycles with clock-regulated metabolic changes optimises metabolism, and studies of other animals suggest that feeding at inappropriate times disrupts circadian system organisation, and thereby contributes to adverse metabolic consequences and chronic disease development. ‘High-fat diets’ (HFD) produce particularly deleterious effects on circadian system organisation in rodents by blunting feeding/fasting cycles. Time-of-day-restricted feeding, where food availability is restricted to a period of several hours, offsets many adverse consequences of HFD in these animals; however, further evidence is required to assess whether the same is true in humans. Several nutritional compounds have robust effects on the circadian system. Caffeine, for example, can speed synchronisation to new time zones after jetlag. An appreciation of the circadian system has many implications for nutritional science and may ultimately help reduce the burden of chronic diseases.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Authors 2016. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | Chrononutrition: Metabolism: Obesity: Time-restricted feeding |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Funding Information: | Funder Grant number MRC G1100235/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 27 May 2016 11:53 |
Last Modified: | 25 May 2017 00:38 |
Published Version: | http://dx.doi.org/10.1017/S0007114516002117 |
Status: | Published |
Publisher: | Cambridge University Press |
Identification Number: | 10.1017/S0007114516002117 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:100205 |