Gupta, A, Monteferrante, C, Rasina, D et al. (7 more authors) (2016) Drug resistance without drug selection: polymorphism in leuS confers reduced susceptibility 1 to GSK2251052 in a clinical isolate of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 60 (5). pp. 3219-3221. ISSN 1098-6596
Abstract
GSK2251052 is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS) that has been evaluated in Phase II clinical trials. Here we report the identification of a clinical isolate of Staphylococcus aureus that exhibits reduced susceptibility to GSK2251052 without prior exposure to the compound, and demonstrate that this phenotype is attributable to a single amino acid polymorphism (P329) within the editing domain of LeuRS.
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Copyright, Publisher and Additional Information: | © 2016, American Society for Microbiology. This is an author produced version of a paper published in Antimicrobial Agents and Chemotherapy. Uploaded in accordance with the publisher's self-archiving policy. | ||||
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Institution: | The University of Leeds | ||||
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) | ||||
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Depositing User: | Symplectic Publications | ||||
Date Deposited: | 19 Jul 2016 09:59 | ||||
Last Modified: | 16 Nov 2016 07:44 | ||||
Published Version: | http://dx.doi.org/10.1128/AAC.02940-15 | ||||
Status: | Published | ||||
Publisher: | American Society for Microbiology | ||||
Identification Number: | https://doi.org/10.1128/AAC.02940-15 |