A Model of the Dynamic Relationship Between Blood Flow and Volume Changes During Brain Activation
Kong, Y., Zheng, Y., Johnston, D. et al. (4 more authors)
(2004)
A Model of the Dynamic Relationship Between Blood Flow and Volume Changes During Brain Activation.
Research Report.
ACSE Research Report 852
.
Department of Automatic Control and Systems Engineering
Abstract
The temporal relationship between changes in cerebral blood flow 9CBF) and cerebral blood volume (CBV) is still poorly understood. Grubb et al. (Grubb et al. 1974) measured steady state relationship between changes in CBV and CBF following hypercapnic challenge which has been used extensively in the modelling of haemodynamic response to activation particularly in the context of magnetic resonance imaging and the blood oxygen level dependent (BOLD) signal. More recently the 'Balloon model' (Buxton et al. 1998) and 'Windkessel model' (Mandeville et al. 1999) have been proposed to describe the temporal dynamics of changes in CBV and CBF. In the study reported here, a model based on the windkessel model incorporating delayed compliance is presented and compared with the original Windkessel model. The modified model is better able to capture the dynamics of CBF and CBV changes, particularly in the later stages.
Metadata
Authors/Creators:
Kong, Y.
Zheng, Y.
Johnston, D.
Martindale, J.
Jones, M.
Billings, S.A.
Mayhew, J.E.W.
Copyright, Publisher and Additional Information:
The Department of Automatic Control and Systems Engineering research reports offer a forum for the research output of the academic staff and research students of the Department at the University of Sheffield. Papers are reviewed for quality and presentation by a departmental editor. However, the contents and opinions expressed remain the responsibility of the authors. Some papers in the series may have been subsequently published elsewhere and you are advised to cite the later published version in these instances.
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