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Hare, C and Ghadiri, M orcid.org/0000-0003-0479-2845 (2015) Attrition of paracetamol and aspirin under bulk shear deformation. Chemical Engineering Science, 125. pp. 13-19. ISSN 0009-2509
Abstract
Particles are frequently exposed to shear stresses during manufacturing, which leads to breakage. This is particularly relevant to weak active pharmaceutical ingredients and is prevalent in pharmaceutical and food industries. The attrition of paracetamol and aspirin caused by shear deformation at very low stresses is investigated here. The extent of breakage of these particles is related to the prevailing shear stresses and strains. In contrast to the expected trend, smaller particles exhibited increased breakage rates. At the onset of shearing at low stresses aspirin particles experienced slightly more breakage than the paracetamol, however prolonged shearing resulted in greater breakage of paracetamol. Breakage occurred initially through chipping with some fragmentation, particularly more noticeable for aspirin, with an increase in abrasion after extensive shear strain for paracetamol. Empirical breakage relationships are proposed and when combined with process stresses and strain analyses the extent of breakage occurring in process equipment can be estimated.
Metadata
Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
Keywords: | Attrition; Breakage; Shear deformation; Particle; Chipping; Fragmentation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Apr 2015 13:08 |
Last Modified: | 02 Mar 2019 17:56 |
Published Version: | http://dx.doi.org/10.1016/j.ces.2014.10.027 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | https://doi.org/10.1016/j.ces.2014.10.027 |
Available Versions of this Item
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Attrition of Paracetamol and Aspirin under bulk shear deformation. (deposited 10 Nov 2014 10:07)
- Attrition of paracetamol and aspirin under bulk shear deformation. (deposited 13 Apr 2015 13:08) [Currently Displayed]