Cohort profile: Evaluation of the Methods and Management of Acute Coronary Events (EMMACE) longitudinal cohort

Abstract

Aims The Evaluation of the Methods and Management of Acute Coronary Events (EMMACE) longitudinal cohort study aims to investigate health trajectories of individuals following hospitalization for myocardial infarction (MI).

Methods and results EMMACE is a linked multicentre prospective cohort study of 14 899 patients with MI admitted to 77 hospitals in England who participated in the EMMACE-3 and -4 studies between 1st November 2011 and 24th June 2015. Long-term follow-up of the EMMACE cohorts was conducted through the EMMACE-XL (27th September 2020 to 31st March 2022) and EMMACE-XXL (1st July 2021 to 1st July 2023) studies. EMMACE collected individual participant data for health-related quality of life (HRQoL) measured by three-level EuroQol five-dimension and visual analogy scale at admission, 1 month, 6 months, 12 months, and 10 years follow-up, as well as medications, medication adherence, beliefs about medicines, Satisfaction with Information about Medicines Scale, and illness perceptions. Participant data were deterministically linked to the Myocardial Infarction National Audit Project (MINAP) for information on baseline treatments and comorbidities, Hospital Episode Statistics Admitted Patient Care (for cause-specific hospitalization data), and the Office for National Statistics (for mortality data) up to 2020.

Conclusion EMMACE is a nationwide prospective cohort that will provide unique insights into fatal and non-fatal outcomes, medication adherence, and HRQoL following MI.

Metadata

Authors/Creators:

Munyombwe, T. https://orcid.org/0000-0002-1307-6691
Dondo, T.B.
Hall, M. https://orcid.org/0000-0003-1246-2627
Nadarajah, R. https://orcid.org/0000-0001-9895-9356
Hurdus, B. https://orcid.org/0000-0001-8149-3449
Aktaa, S.
Haris, M.
Keeley, A.
West, R. https://orcid.org/0000-0001-7305-3654
Hall, A.
Soloveva, A. https://orcid.org/0000-0002-0013-0660
Norman, P. https://orcid.org/0000-0002-6211-1625
Gale, C.P. https://orcid.org/0000-0003-4732-382X

© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

Keywords:

Myocardial infarction, Outcomes, Hospitalizations, Medications, Health-related quality of life, Cohort, Electronic health records, Longitudinal data

Dates: