Research priorities in prehabilitation for patients undergoing cancer surgery: an international Delphi study

Abstract

Background Recently, the number of prehabilitation trials has increased significantly. The identification of key research priorities is vital in guiding future research directions. Thus, the aim of this collaborative study was to define key research priorities in prehabilitation for patients undergoing cancer surgery.

Methods The Delphi methodology was implemented over three rounds of surveys distributed to prehabilitation experts from across multiple specialties, tumour streams and countries via a secure online platform. In the first round, participants were asked to provide baseline demographics and to identify five top prehabilitation research priorities. In successive rounds, participants were asked to rank research priorities on a 5-point Likert scale. Consensus was considered if > 70% of participants indicated agreement on each research priority.

Results A total of 165 prehabilitation experts participated, including medical doctors, physiotherapists, dieticians, nurses, and academics across four continents. The first round identified 446 research priorities, collated within 75 unique research questions. Over two successive rounds, a list of 10 research priorities reached international consensus of importance. These included the efficacy of prehabilitation on varied postoperative outcomes, benefit to specific patient groups, ideal programme composition, cost efficacy, enhancing compliance and adherence, effect during neoadjuvant therapies, and modes of delivery.

Conclusions This collaborative international study identified the top 10 research priorities in prehabilitation for patients undergoing cancer surgery. The identified priorities inform research strategies, provide future directions for prehabilitation research, support resource allocation and enhance the prehabilitation evidence base in cancer patients undergoing surgery.

Metadata

Authors/Creators:	Raichurkar, P. Denehy, L. Solomon, M. Koh, C. Pillinger, N. Hogan, S. McBride, K. Carey, S. Bartyn, J. Hirst, N. Steffens, D. https://orcid.org/0000-0002-9715-860X Allen, J. Ancog, K. Angenete, E. Ansari, N. Ausania, F. Beaumont, A. Beilstein, C. Berrevoet, F. Boden, I. Bostock, K. Bothe, J. Brandstrup, B. Brennan, L. Brown, K. Burden, S. Burgess, C. Burns, E. Carli, F. Cavalheri, V. Ceelen, W. Chesney, T. Clark, D. Clifford, K. Cole, K. Collyer, T. Copeland, R. Croner, R. Crowe, J. Daniels, I. Danjoux, G. Davis, J. Davis, C. de Klerk, M. Decorte, T. Dekker, J.W. Denys, A. Desender, L. Dries, P. Dunne, D. Edbrooke, L. Edgar, L. Eissa, S. Engel, D. Evans, M. Farrell, R. Finch, A. Fleury, A. Forget, P. Francis, N. Frizelle, F. Frontera, W. Geboes, K. Giddings, H. Gillespie, C. Gillis, C. Glehen, O. Gorey, V. Granger, C. Greenfield, D. https://orcid.org/0000-0002-3733-2717 Griffiths, B. Grimmett, C. Hackett, C. Hall, T. Hallet, J. Harris, C. Hatcher, S. Hendriks, L. Hermans, M. Ilyas, C. Ismail, H. Jenkins, J. Jiang, W. Johnstone, C. Karakatsanis, A. Karunaratne, S. Kaur, S. Kelly, M. Klaase, J. Kršul, D. Leslie, S. Loeliger, J. Lydrup, M.-L. Maier, A. Major, P. Makker, P. Mantyh, C. McCluskey, S. McGarrity, L. Moloney, J. Montroni, I. Moran, B. Morris, P. Moug, S. Ms, R. Murdoch, S. Myers, A. Ng, K.-S. Nilsson, P.J. Noordzij, P. O’Connor, M. Pellino, G. Philp, S. Pocard, M. Puthucheary, Z. Putrus, E. Quyn, A. Read, T. Ricketts, W. Riedel, B. Rutten, H. Sabajo, C. Salihi, R. Sammour, T. Sandroussi, C. Mina, D.S. Saric, S. Sebio, R. Seyfi, D. Singh, F. Slooter, G. Smart, N. Spencer, L. Sutton, P. Tan, H.E. Cate, D.T. Turna, A. Van Daele, E. van den Berg, A. van Kessel, C. van Ramshorst, G. Verdaasdonk, E. Vu, J. Wakeman, C. West, M. Wheeler, J. Wijeysundera, D. Yano, H.
Copyright, Publisher and Additional Information:	© 2023 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	Cancer; Delphi; Perioperative care; Prehabilitation; Research priorities; Surgery; Humans; Delphi Technique; Preoperative Exercise; Physicians; Research Design; Neoplasms
Dates:	Accepted: 6 August 2023 Published (online): 24 August 2023 Published: November 2023
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Depositing User:	Symplectic Sheffield
Date Deposited:	24 Nov 2023 10:36
Last Modified:	24 Nov 2023 10:36
Published Version:	http://dx.doi.org/10.1245/s10434-023-14192-x
Status:	Published
Publisher:	Springer Science and Business Media LLC
Refereed:	Yes
Identification Number:	https://doi.org/10.1245/s10434-023-14192-x
Related URLs:	PubMed URL

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Research priorities in prehabilitation for patients undergoing cancer surgery: an international Delphi study

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