Jolugbo, P. orcid.org/0000-0001-6487-8558, Willott, T., Lin, W-H. et al. (5 more authors) (2023) Fluorescent imaging using novel conjugated polymeric nanoparticles-affimer probes in complex in vitro models of colorectal cancer. Nanoscale, 15 (30). pp. 12476-12480. ISSN 2040-3364
Abstract
We developed a carcinoembryonic antigen (CEA) conjugated polymer nanoparticle (CPN510-CEA-Af) probe to target CEA-expressing CRC cells in vitro. Its efficacy was evaluated in 2D and 3D cultures of LS174T, LoVo, and HT29 CRC cell lines. CPN510-CEA-Af produced greater fluorescent signal intensity than unconjugated particles in both 2D cells and 3D spheriods, indicating its potential as a probe for image-guided colorectal cancer surgery.
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Copyright, Publisher and Additional Information: | This item is protected by copyright. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. | ||||
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Institution: | The University of Leeds | ||||
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) > Trans Anaesthetics & Surgical Sciences (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Medical Research (LIMR) > Division of Gastroenterology and Surgery |
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Depositing User: | Symplectic Publications | ||||
Date Deposited: | 06 Sep 2023 10:40 | ||||
Last Modified: | 06 Sep 2023 10:40 | ||||
Status: | Published | ||||
Publisher: | Royal Society of Chemistry | ||||
Identification Number: | https://doi.org/10.1039/d3nr02160b |