Hyperpolarized 13C magnetic resonance imaging of fumarate metabolism by parahydrogen-induced polarization: a proof-of-concept in vivo study

Abstract

The front cover artwork is provided by the group of Dr. Neil J. Stewart, Prof. Hiroshi Hirata, and Dr. Shingo Matsumoto (Hokkaido University, Japan) as well as Dr. Takuya Hashimoto (Chiba University, Japan). The image shows hyperpolarized 13C fumarate metabolism to hyperpolarized 13C malate, which is released into the extracellular space in regions of necrotic cell death, where the cell membrane is disrupted. Read the full text of the Article at 10.1002/cphc.202001038.

Metadata

Authors/Creators:

Stewart, N.J. https://orcid.org/0000-0001-8358-394X
Nakano, H.
Sugai, S.
Tomohiro, M.
Kase, Y.
Uchio, Y.
Yamaguchi, T. https://orcid.org/0000-0002-7183-7209
Matsuo, Y.
Naganuma, T.
Takeda, N.
Nishimura, I.
Hirata, H.
Hashimoto, T.
Matsumoto, S. https://orcid.org/0000-0003-2698-0839

Keywords:

Biomedical Imaging

Dates:

Published (online): 17 May 2021
Published: 17 May 2021

Institution:

The University of Sheffield

Academic Units:

The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield)
The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health

Funding Information:

Funder	Grant number
Japan Society for the Promotion of Science	http://dx.doi.org/10.13039/501100001691
Japan Society for the Promotion of Science	18F18114

Depositing User:

Symplectic Sheffield

Date Deposited:

31 Aug 2023 13:37

Last Modified:

31 Aug 2023 13:37

Status:

Published

Publisher:

Wiley

Refereed:

Yes

Identification Number:

https://doi.org/10.1002/cphc.202100338

Related URLs:

PubMed URL

CORE (COnnecting REpositories)

Hyperpolarized 13C magnetic resonance imaging of fumarate metabolism by parahydrogen-induced polarization: a proof-of-concept in vivo study

Abstract

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