Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model

Abstract

Background: Increased coronary microvascular resistance (CMVR) is associated with coronary microvascular dysfunction (CMD). Although CMD is more common in women, sex-specific differences in CMVR have not been demonstrated previously.

Aim: To compare CMVR between men and women being investigated for chest pain.

Methods and results: We used a computational fluid dynamics (CFD) model of human coronary physiology to calculate absolute CMVR based on invasive coronary angiographic images and pressures in 203 coronary arteries from 144 individual patients. CMVR was significantly higher in women than men (860 [650–1,205] vs. 680 [520–865] WU, Z = −2.24, p = 0.025). None of the other major subgroup comparisons yielded any differences in CMVR.

Metadata

Authors/Creators:	Taylor, D.J. Aubiniere-Robb, L. Gosling, R. Newman, T. Hose, D.R. Halliday, I. Lawford, P.V. Narracott, A.J. Gunn, J.P. Morris, P.D.
Copyright, Publisher and Additional Information:	© 2023 Taylor, Aubiniere-Robb, Gosling, Newman, Hose, Halliday, Lawford, Narracott, Gunn and Morris. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. https://creativecommons.org/licenses/by/4.0/
Keywords:	Clinical Research; Heart Disease; Cardiovascular; Heart Disease - Coronary Heart Disease; Cardiovascular
Dates:	Accepted: 22 June 2023 Published (online): 6 July 2023 Published: 6 July 2023
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	26 Jul 2023 14:02
Last Modified:	26 Jul 2023 14:02
Status:	Published
Publisher:	Frontiers Media SA
Refereed:	Yes
Identification Number:	https://doi.org/10.3389/fcvm.2023.1159160

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Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model

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