Burge, Rebecca J., Mottram, Jeremy C. orcid.org/0000-0001-5574-3766 and Wilkinson, Anthony J. orcid.org/0000-0003-4577-9479 (2022) Ubiquitin and ubiquitin-like conjugation systems in trypanosomatids. Current Opinion in Microbiology. 102202. ISSN 1369-5274
Abstract
In eukaryotic cells, reversible attachment of ubiquitin and ubiquitin-like modifiers (Ubls) to specific target proteins is conducted by multicomponent systems whose collective actions control protein fate and cell behaviour in precise but complex ways. In trypanosomatids, attachment of ubiquitin and Ubls to target proteins regulates the cell cycle, endocytosis, protein sorting and degradation, autophagy and various aspects of infection and stress responses. The extent of these systems in trypanosomatids has been surveyed in recent reports, while in Leishmania mexicana, essential roles have been defined for many ubiquitin-system genes in deletion mutagenesis and life-cycle phenotyping campaigns. The first steps to elucidate the pathways of ubiquitin transfer among the ubiquitination components and to define the acceptor substrates and the downstream deubiquitinases are now being taken.
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Copyright, Publisher and Additional Information: | Funding Information: This work was supported by a Medical Research Council Studentship to RB ( MRC MR/N018230/ ) and the Wellcome Trust to JCM ( 200807/Z/16/Z ). Publisher Copyright: © 2022 The Authors | ||||||
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Institution: | The University of York | ||||||
Academic Units: | The University of York > Faculty of Sciences (York) > Centre for Immunology and Infection (CII) (York) The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Chemistry (York) |
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Depositing User: | Pure (York) | ||||||
Date Deposited: | 11 Jul 2023 10:10 | ||||||
Last Modified: | 04 Feb 2024 01:23 | ||||||
Published Version: | https://doi.org/10.1016/j.mib.2022.102202 | ||||||
Status: | Published | ||||||
Refereed: | Yes | ||||||
Identification Number: | https://doi.org/10.1016/j.mib.2022.102202 | ||||||
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