Nanoparticles Isolated From Porcine Bone Soup Ameliorated Dextran Sulfate Sodium-Induced Colitis and Regulated Gut Microbiota in Mice

Daily foods contain a great number of self-assembled nanoparticles (NPs) which were

incidentally produced during food processing. These food incidental NPs can directly

access the human gastrointestinal tract in high frequency and large quantities. Limited

reports were focused on whether and how these food incidental NPs affected the

gastrointestinal tissues and gut microbiota. In the present study, bone soup and its

NPs both significantly ameliorated colitis symptoms in dextran sulfate sodium (DSS)-

induced mice and inhibited the release of pro-inflammatory cytokines. They also restored

intestinal microbiota dysbiosis by improving the diversity and richness of intestinal

microbiota and regulating community composition, such as a remarkable increase in

Muribaculaceae, Alistipes, and Alloprevotella, and a decrease in Helicobacter. Moreover,

the correlation analysis showed that pro-inflammatory cytokines were negatively

correlated with Muribaculaceae, Alloprevotella, and Alistipes, but positively correlated

with Helicobacter. These findings suggest that the food incidental NPs can influence

human health through regulating the inflammation of the gastrointestinal tissues and the

gut microbiota