A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins

Castelli, L.M., Lin, Y.-H., Sanchez-Martinez, A. et al. (19 more authors) (2023) A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. Science Translational Medicine, 15 (685). ISSN 1946-6234

Abstract

Metadata

Authors/Creators:
  • Castelli, L.M.
  • Lin, Y.-H.
  • Sanchez-Martinez, A.
  • Gül, A.
  • Imran, K.M
  • Higginbottom, A.
  • Márkus, N.M.
  • Upadhyay, S.K.
  • Martins, A.W.
  • Cooper-Knock, J.
  • Montmasson, C.
  • Cohen, R.
  • Walton, A.
  • Bauer, C.S.
  • De Vos, K.J.
  • Mead, R.J.
  • Azzouz, M.
  • Dominguez, C.
  • Ferraiuolo, L.
  • Shaw, P.
  • Whitworth, A.J.
  • Hautbergue, G. ORCID logo https://orcid.org/0000-0002-1621-261X
Copyright, Publisher and Additional Information: © 2023 The Authors, some rights reserved, exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This author manuscript is distributed under the terms of the CC BY ND Creative Commons Attribution license (https://creativecommons.org/licenses/by-nd/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Dates:
  • Accepted: 7 February 2023
  • Published (online): 1 March 2023
  • Published: 1 March 2023
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield)
Funding Information:
FunderGrant number
MEDICAL RESEARCH COUNCILMR/R024162/1
MOTOR NEURONE DISEASE ASSOCIATIONMND005891
BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCILBB/S005277/1
LIFEARCUNSPECIFIED
Depositing User: Symplectic Sheffield
Date Deposited: 08 Mar 2023 18:58
Last Modified: 08 Mar 2023 22:54
Status: Published
Publisher: American Association for the Advancement of Science
Refereed: Yes
Identification Number: https://doi.org/10.1126/scitranslmed.abo3823

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