Cooper, K. orcid.org/0000-0002-7702-8103, Essat, M., Bessey, A. et al. (3 more authors) (2022) Diagnostic accuracy of biopsy versus full excision for diagnosis of oral cancer: a systematic review. Report. ScHARR HEDS Discussion Papers . School of Health and Related Research, University of Sheffield
Abstract
Objectives: To review studies assessing diagnostic accuracy of biopsy of oral lesions for diagnosis of oral cancer and potentially malignant disorders, compared with full excision.
Methods: Systematic review: four databases were searched for studies conducted within developed countries and published between 2009 and January 2020.
Results: Six studies met inclusion criteria, with wide variation in methods and results. For identifying dysplasia or malignancy, sensitivity of biopsy (versus excision) ranged from 42% to 86% and specificity from 75% to 100% across two studies, while concordance varied from 27% to 89% across four studies. For identifying malignant-only lesions, sensitivity was 71% and 94% in two studies, while specificity ranged from 17% to 100% across four studies.
Conclusions: There are few published studies assessing biopsy accuracy, with varying results. Further research should evaluate factors impacting accuracy, such as biopsy depth; multiple biopsies of large lesions; discordance between pathologists; and regular follow-up.
Metadata
Item Type: | Monograph |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Author(s). Article available under the terms of the CC-BY-NC-ND 4.0 licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
Keywords: | Oral cancer; biopsy; diagnostic tests; sensitivity and specificity; systematic review |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Health Economics and Decision Science > HEDS Discussion Paper Series |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 30 Nov 2022 13:01 |
Last Modified: | 01 Dec 2022 09:12 |
Status: | Published |
Publisher: | School of Health and Related Research, University of Sheffield |
Series Name: | ScHARR HEDS Discussion Papers |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:193922 |
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Licence: CC-BY-NC-ND 4.0