Al-enabled, implantable, multichannel wireless telemetry for photodynamic therapy

Photodynamic therapy (PDT) is an alternative method for treating cancers, and its outcomes are highly dependent on light delivery to tumor cells to activate a photosensitizer. Existing approaches paired with advances in wireless technologies enable remote delivery of light to tumors but suffer from poor spatiotemporal resolution due to inabilities to minimize oxygen depletion in a tumor. Here, we introduce AI-informed low-power wireless telemetry with an integrated thermal/light simulation platform that bypasses all constraints above. The simulator leads to the optimized combination of wavelengths and light sources, and AI-assisted wireless telemetry uses the parameters from the simulator to enable adequate illumination of tumors through high-throughput (< 20 mice) and multi-wavelength operation. They establish a range of guidelines for effective PDT regimen design. Hypericin and Foscan mediated PDT demonstrated substantial suppression of tumor growth, suggesting that the proposed platform provides the potential for widespread use in fundamental research and/or clinical settings.