Cardiovascular magnetic resonance imaging and spectroscopy in clinical long-COVID-19 syndrome: a prospective case–control study

Abstract

Background

The underlying pathophysiology of post-coronavirus disease 2019 (long-COVID-19) syndrome remains unknown, but increased cardiometabolic demand and state of mitochondrial dysfunction have emerged as candidate mechanisms. Cardiovascular magnetic resonance (CMR) provides insight into pathophysiological mechanisms underlying cardiovascular disease and 31-phosphorus CMR spectroscopy (31P-CMRS) allows non-invasive assessment of the myocardial energetic state. The main aim of the study was to assess whether long COVID-19 syndrome is associated with abnormalities of myocardial structure, function, perfusion and energy metabolism.

Methods

Prospective case–control study. A total of 20 patients with a clinical diagnosis of long COVID-19 syndrome (seropositive) and no prior underlying cardiovascular disease (CVD) and 10 matching healthy controls underwent 31P-CMRS and CMR at 3T at a single time point. All patients had been symptomatic with acute COVID-19, but none required hospital admission.

Results

Between the long COVID-19 syndrome patients and matched contemporary healthy controls there were no differences in myocardial energetics (phosphocreatine to ATP ratio), in cardiac structure (biventricular volumes), function (biventricular ejection fractions, global longitudinal strain), tissue characterization (T1 mapping and late gadolinium enhancement) or perfusion (myocardial rest and stress blood flow, myocardial perfusion reserve). One patient with long COVID-19 syndrome showed subepicardial hyperenhancement on late gadolinium enhancement imaging compatible with prior myocarditis, but no accompanying abnormality in cardiac size, function, perfusion, extracellular volume fraction, native T1, T2 or cardiac energetics.

Conclusions

In this prospective case–control study, the overwhelming majority of patients with a clinical long COVID-19 syndrome with no prior CVD did not exhibit any abnormalities in myocardial energetics, structure, function, blood flow or tissue characteristics.

Metadata

Authors/Creators:

Gorecka, M https://orcid.org/0000-0002-5688-8980
Jex, N
Thirunavukarasu, S
Chowdhary, A
Corrado, J
Davison, J
Tarrant, R
Poenar, A-M
Sharrack, N https://orcid.org/0000-0001-5880-1722
Parkin, A
Sivan, M https://orcid.org/0000-0002-0334-2968
Swoboda, PP https://orcid.org/0000-0001-7162-7079
Xue, H
Vassiliou, V
Kellman, P
Plein, S https://orcid.org/0000-0002-0997-4384
Halpin, SJ https://orcid.org/0000-0002-0417-8928
Simms, AD
Greenwood, JP https://orcid.org/0000-0002-2861-0914
Levelt, E https://orcid.org/0000-0002-3799-7102

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Keywords:

31-phosphorus magnetic resonance spectroscopy; COVID-19; Cardiovascular magnetic resonance imaging; LONG COVID; Post-COVID-19 syndrome; COVID-19; Case-Control Studies; Contrast Media; Gadolinium; Humans; Magnetic Resonance Imaging; Myocarditis; Predictive Value of Tests; Spectrum Analysis

Dates: