Clonal dynamics of haematopoiesis across the human lifespan

Mitchell, Emily, Spencer Chapman, Michael, Williams, Nicholas et al. (26 more authors) (2022) Clonal dynamics of haematopoiesis across the human lifespan. Nature. pp. 343-350. ISSN 0028-0836

Abstract

Metadata

Authors/Creators:
  • Mitchell, Emily
  • Spencer Chapman, Michael
  • Williams, Nicholas
  • Dawson, Kevin J.
  • Mende, Nicole
  • Calderbank, Emily F.
  • Jung, Hyunchul
  • Mitchell, Thomas
  • Coorens, Tim H.H.
  • Spencer, David H.
  • Machado, Heather
  • Lee-Six, Henry
  • Davies, Megan
  • Hayler, Daniel
  • Fabre, Margarete A.
  • Mahbubani, Krishnaa
  • Abascal, Federico
  • Cagan, Alex
  • Vassiliou, George S.
  • Baxter, Joanna
  • Martincorena, Inigo
  • Stratton, Michael R.
  • Kent, David G. (david.kent@york.ac.uk)
  • Chatterjee, Krishna
  • Parsy, Kourosh Saeb
  • Green, Anthony R.
  • Nangalia, Jyoti
  • Laurenti, Elisa
  • Campbell, Peter J.
Copyright, Publisher and Additional Information: Funding Information: This work was supported by the WBH Foundation. Investigators at the Sanger Institute are supported by a core grant from the Wellcome Trust. P.J.C. was a Wellcome Trust Senior Clinical Fellow (WT088340MA) until 2020. N.M. was supported by a DFG Research Fellowship (ME 5209/1-1). Work in the D.G.K. laboratory is supported by a Bloodwise Bennett Fellowship (15008), a Cancer Research UK Programme Foundation Award (DCRPGF\100008), and a European Research Council Starting Grant (ERC-2016-STG–715371). Work in the A.R.G. laboratory is supported by the Wellcome Trust, Bloodwise, Cancer Research UK, the Kay Kendall Leukaemia Fund, and the Leukemia and Lymphoma Society of America. Work in the E.L. laboratory is supported by a Wellcome Trust Sir Henry Dale Fellowship, BBSRC and a European Haematology Association Non-Clinical Advanced Research Fellowship. The E.L. and A.R.G. laboratories are supported by a core support grant from the Wellcome Trust and Medical Research Council to the Cambridge Stem Cell Institute. K.M. is supported by the Chan-Zuckerberg Initiative. K.C. is supported by a Wellcome Investigator award (210755/Z/18/Z). We thank the Cambridge Blood and Stem Cell Biobank; the Cambridge Biorepository for Translational Medicine for access to human bone marrow and matched peripheral blood; and the Cambridge NIHR BRC Cell Phenotyping Hub for their flow cytometry services and advice. We acknowledge further assistance from the National Institute for Health Research Cambridge Biomedical Research Centre and the Cambridge Experimental Cancer Medicine Centre. We are grateful to the donors, families of donors and the Cambridge Biorepository for Translational Medicine for the gift of tissues. We thank T. Ley for his help with analysis of AML genomes. For the purpose of Open Access, the author has applied a CC-BY public copyright license to any Author Accepted Manuscript version arising from this submission. This research was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Funding Information: This work was supported by the WBH Foundation. Investigators at the Sanger Institute are supported by a core grant from the Wellcome Trust. P.J.C. was a Wellcome Trust Senior Clinical Fellow (WT088340MA) until 2020. N.M. was supported by a DFG Research Fellowship (ME 5209/1-1). Work in the D.G.K. laboratory is supported by a Bloodwise Bennett Fellowship (15008), a Cancer Research UK Programme Foundation Award (DCRPGF\100008), and a European Research Council Starting Grant (ERC-2016-STG–715371). Work in the A.R.G. laboratory is supported by the Wellcome Trust, Bloodwise, Cancer Research UK, the Kay Kendall Leukaemia Fund, and the Leukemia and Lymphoma Society of America. Work in the E.L. laboratory is supported by a Wellcome Trust Sir Henry Dale Fellowship, BBSRC and a European Haematology Association Non-Clinical Advanced Research Fellowship. The E.L. and A.R.G. laboratories are supported by a core support grant from the Wellcome Trust and Medical Research Council to the Cambridge Stem Cell Institute. K.M. is supported by the Chan-Zuckerberg Initiative. K.C. is supported by a Wellcome Investigator award (210755/Z/18/Z). We thank the Cambridge Blood and Stem Cell Biobank; the Cambridge Biorepository for Translational Medicine for access to human bone marrow and matched peripheral blood; and the Cambridge NIHR BRC Cell Phenotyping Hub for their flow cytometry services and advice. We acknowledge further assistance from the National Institute for Health Research Cambridge Biomedical Research Centre and the Cambridge Experimental Cancer Medicine Centre. We are grateful to the donors, families of donors and the Cambridge Biorepository for Translational Medicine for the gift of tissues. We thank T. Ley for his help with analysis of AML genomes. For the purpose of Open Access, the author has applied a CC-BY public copyright license to any Author Accepted Manuscript version arising from this submission. This research was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Publisher Copyright: © 2022, The Author(s).
Dates:
  • Accepted: 19 April 2022
  • Published: 1 June 2022
Institution: The University of York
Academic Units: The University of York > Faculty of Sciences (York) > Centre for Immunology and Infection (CII) (York)
The University of York > Faculty of Sciences (York) > Biology (York)
Funding Information:
FunderGrant number
EUROPEAN COMMISSION715371
BLOOD CANCER UK.
Depositing User: Pure (York)
Date Deposited: 28 Jul 2022 08:20
Last Modified: 02 Feb 2023 00:50
Published Version: https://doi.org/10.1038/s41586-022-04786-y
Status: Published
Refereed: Yes
Identification Number: https://doi.org/10.1038/s41586-022-04786-y
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Description: Clonal dynamics of haematopoiesis across the human lifespan

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