Wagner, V.P., Bingle, C.D. orcid.org/0000-0002-5405-6988 and Bingle, L. orcid.org/0000-0002-4587-9384 (2022) MYB-NFIB fusion transcript in adenoid cystic carcinoma : current state of knowledge and future directions. Critical Reviews in Oncology/Hematology, 176. 103745. ISSN 1040-8428
Abstract
Adenoid cystic carcinoma (ACC) is the most common type of salivary gland cancer that can also arise in other primary sites. Regardless of the site, most ACC cases carry a recurrent chromosomal translocation - t(6;9)(q22–23;p23–24) - involving the MYB oncogene and the NFIB transcription factor. Generally, a long sequence of MYB is fused to the terminal exons of NFIB, yet the break can occur in different exons for both genes, resulting in multiple chimeric variants. The fusion status can be determined by a number of methods, each of them with particular advantages. In vitro and in vivo studies have been conducted to understand the biological consequences of MYB-NFIB translocation, and such findings could contribute to improving the current inefficient therapeutic options for disseminated ACC. This review provides a discussion on relevant evidence in the context of ACC MYB-NFIB translocations to determine the current state of knowledge and discuss future directions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Head and neck neoplasms; chromosomal translocation; fusion proteins; oncogenes; salivary gland tumors |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number European Commission - HORIZON 2020 894938 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Jul 2022 09:56 |
Last Modified: | 08 Jul 2022 17:42 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.critrevonc.2022.103745 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:188839 |