da Rosa, Gabriela, Grille, Leandro, Calzada, Victoria et al. (23 more authors) (2021) Sequence-dependent structural properties of B-DNA : what have we learned in 40 years? Biophysical Reviews. pp. 995-1005. ISSN 1867-2450
Abstract
The structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA to recognize ligands and consequently on its functionality. In this sense, the knowledge obtained from the sequence-dependent structural properties of B-DNA has always been thought crucial to rationalize how ligands and, most notably, proteins recognize B-DNA and modulate its activity, i.e. the structural basis of gene regulation. Honouring the anniversary of the first high-resolution X-ray structure of a B-DNA molecule, in this contribution, we present the most important discoveries of the last 40 years on the sequence-dependent structural and dynamical properties of B-DNA, from the early beginnings to the current frontiers in the field.
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Copyright, Publisher and Additional Information: | © International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2021. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details | ||||
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Institution: | The University of York | ||||
Academic Units: | The University of York > Faculty of Sciences (York) > Physics (York) | ||||
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Depositing User: | Pure (York) | ||||
Date Deposited: | 06 Jul 2022 08:20 | ||||
Last Modified: | 06 Dec 2023 14:36 | ||||
Published Version: | https://doi.org/10.1007/s12551-021-00893-8 | ||||
Status: | Published | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1007/s12551-021-00893-8 |
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