Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses.

Meng, J.X., Zhang, Y., Saman, D. et al. (15 more authors) (2022) Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses. Nature Communications, 13. 2692. ISSN 2041-1723



  • Meng, J.X.
  • Zhang, Y.
  • Saman, D.
  • Haider, A.M.
  • De, S. ORCID logo https://orcid.org/0000-0003-1675-0773
  • Sang, J.C.
  • Brown, K.
  • Jiang, K.
  • Humphrey, J.
  • Julian, L.
  • Hidari, E.
  • Lee, S.F.
  • Balmus, G.
  • Floto, R.A.
  • Bryant, C.E.
  • Benesch, J.L.P.
  • Ye, Y.
  • Klenerman, D.
Copyright, Publisher and Additional Information: © The Author(s) 2022. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Cellular imaging; Intrinsically disordered proteins; Mass spectrometry; Post-translational modifications; Protein aggregation
  • Accepted: 28 April 2022
  • Published (online): 16 May 2022
  • Published: 16 May 2022
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 18 May 2022 15:40
Last Modified: 18 May 2022 15:40
Status: Published
Publisher: Nature Research (part of Springer Nature)
Refereed: Yes
Identification Number: https://doi.org/10.1038/s41467-022-30461-x
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