Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study

Abstract

Purpose

The Quality of Life Alzheimer’s Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available.

Methods

Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error.

Results

The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset.

Conclusions

The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.

Metadata

Authors/Creators:	Rombach, I. https://orcid.org/0000-0003-3464-3867 Iftikhar, M. Jhuti, G.S. Gustavsson, A. Lecomte, P. Belger, M. Handels, R. Castro Sanchez, A.Y. Kors, J. Hopper, L. Olde Rikkert, M. Selbæk, G. Stephan, A. Sikkes, S.A.M. Woods, B. Gonçalves-Pereira, M. Zanetti, O. Ramakers, I.H.G.B. Verhey, F.R.J. Gallacher, J. Actifcare Consortium LeARN Consortium Landeiro, F. Gray, A.M. ROADMAP Consortium
Copyright, Publisher and Additional Information:	© The Author(s) 2020. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	Mapping algorithm; Cross-walking; Health related quality of life; Preference based measures; Dementia
Dates:	Accepted: 3 October 2020 Published (online): 17 October 2020 Published: March 2021
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research
Depositing User:	Symplectic Sheffield
Date Deposited:	09 May 2022 15:41
Last Modified:	11 May 2022 04:04
Status:	Published
Publisher:	Springer Science and Business Media LLC
Refereed:	Yes
Identification Number:	https://doi.org/10.1007/s11136-020-02670-8
Related URLs:	Author

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Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study

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