Norquay, G. orcid.org/0000-0002-4108-9035, Collier, G.J. orcid.org/0000-0002-1874-4775, Rodgers, O.I. et al. (3 more authors) (2022) Standalone portable xenon-129 hyperpolariser for multicentre clinical magnetic resonance imaging of the lungs. The British Journal of Radiology, 95 (1132). bjr.20210872. ISSN 0007-1285
Abstract
Objectives
Design and build a portable xenon-129 (129Xe) hyperpolariser for clinically accessible 129Xe lung MRI.
Methods
The polariser system consists of six main functional components: (i) a laser diode array and optics; (ii) a B0 coil assembly; (iii) an oven containing an optical cell; (iv) NMR and optical spectrometers; (v) a gas-handling manifold; and (vi) a cryostat within a permanent magnet. All components run without external utilities such as compressed air or three-phase electricity, and require just three mains sockets for operation. The system can be manually transported in a lightweight van and rapidly installed on a small estates footprint in a hospital setting.
Results
The polariser routinely provides polarised 129Xe for routine clinical lung MRI. To test the concept of portability and rapid deployment, it was transported 200 km, installed at a hospital with no previous experience with the technology and 129Xe MR images of a diagnostic quality were acquired the day after system transport and installation.
Conclusion
This portable 129Xe hyperpolariser system could form the basis of a cost-effective platform for wider clinical dissemination and multicentre evaluation of 129Xe lung MR imaging.
Metadata
Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. | ||||||||
Dates: |
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Institution: | The University of Sheffield | ||||||||
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals | ||||||||
Funding Information: |
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Depositing User: | Symplectic Sheffield | ||||||||
Date Deposited: | 26 Apr 2022 14:24 | ||||||||
Last Modified: | 27 Apr 2022 09:41 | ||||||||
Status: | Published | ||||||||
Publisher: | British Institute of Radiology | ||||||||
Refereed: | Yes | ||||||||
Identification Number: | https://doi.org/10.1259/bjr.20210872 | ||||||||
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