Do side effects to the primary COVID-19 vaccine reduce intentions for a COVID-19 vaccine booster?

Background

Vaccines are being administered worldwide to combat the COVID-19 pandemic. Vaccine boosters are essential for maintaining immunity and protecting against virus variants. The side effects of the primary COVID-19 vaccine (e.g., headache, nausea), however, could reduce intentions to repeat the vaccination experience, thereby hindering global inoculation efforts.

Purpose

The main aim of this research was to test whether side effects to a primary COVID19 vaccine relate to reduced intentions to receive a COVID-19 booster. The second aim was to explore psychological and demographic predictors of booster intentions.

Methods Secondary data analyses were conducted on a US national sample of 551 individuals recruited through the online platform Prolific. Key measures in the data set were side effects reported from a primary COVID-19 vaccination and subsequent intentions to receive a booster vaccine. Psychological and demographic variables that predicted primary vaccination intentions in prior studies were also measured.

Results

Booster intentions were high. COVID-19 booster vaccine intentions were uncorrelated with the number of side effects, intensity of side effects, or occurrence of an intense side effect from the primary COVID-19 vaccine. Correlational and regression analyses indicated intentions for a booster vaccination increased with positive vaccination attitudes, trust in vaccine development, worry about the COVID-19 pandemic, low concern over vaccine side effects, and Democratic political party affiliation.

Conclusions

Side effects to a primary COVID-19 vaccine were not directly associated with lower intentions to receive a booster of the COVID-19 vaccine. However, many variables that predict primary vaccination intentions also predict booster intentions.