Derbyshire, AE, MacKintosh, ML, Pritchard, CM et al. (5 more authors) (2022) Women’s Risk Perceptions and Willingness to Engage in Risk-Reducing Interventions for the Prevention of Obesity-Related Endometrial Cancer. International Journal of Women's Health, Volume 14. pp. 57-66. ISSN 1179-1411
Abstract
Introduction: Endometrial cancer rates are rising in parallel with the global obesity epidemic. Our aim was to assess the willingness of women at greatest risk of obesity-related endometrial cancer to engage with risk-reducing strategies and establish perceived barriers that may preclude their participation in a randomized controlled trial of primary endometrial cancer prevention.
Materials and Methods: Women attending gynecology, obesity and sleep apnea clinics in Manchester Academic Health Sciences Centre-affiliated hospitals with obesity classes II (BMI 35– 39.9kg/m2) and III (BMI ≥ 40kg/m2) were invited to participate in a cross-sectional survey. We asked women about their perceived risk, knowledge of risk factors and willingness to engage with endometrial cancer risk-reducing interventions.
Results: Seventy-four women with a median age of 51 years (range 22– 73) and BMI of 47kg/m2 (range 34– 81) took part in the study. Two-thirds (65.6%) knew that obesity was a risk factor for endometrial cancer but few were able to recall other major risk factors. Just over half (53.5%) perceived their risk of developing endometrial cancer to be higher than average. Women were prepared to lose weight (94%), eat healthily (91%), exercise more (87%), take a pill every day (74%) or receive an intra-uterine device (49%) for primary endometrial cancer prevention. Perceived barriers included cost, forgetting, willpower, finding time, physical fitness, social anxiety, possible side effects and previous bad experiences.
Conclusion: Women at highest risk of obesity-related endometrial cancer may not always appreciate their susceptibility. However, willingness to engage in risk-reducing strategies suggests recruitment to a randomized controlled trial for primary endometrial cancer prevention could be feasible.
Metadata
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Copyright, Publisher and Additional Information: | © 2022 Derbyshire et al. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) | ||||
Keywords: | endometrial cancer; obesity; risk reducing interventions; weight loss; exercise; chemoprevention; levonorgestrel-releasing intrauterine system; metformin | ||||
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Institution: | The University of Leeds | ||||
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Depositing User: | Symplectic Publications | ||||
Date Deposited: | 22 Feb 2022 15:45 | ||||
Last Modified: | 22 Feb 2022 15:45 | ||||
Status: | Published | ||||
Publisher: | Dove Medical Press | ||||
Identification Number: | https://doi.org/10.2147/ijwh.s326417 | ||||
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