El-Howati, A., Thornhill, M. orcid.org/0000-0003-0681-4083, Colley, H. et al. (1 more author) (2023) Immune mechanisms in oral lichen plants. Oral Diseases, 29 (4). pp. 1400-1415. ISSN 1354-523X
Abstract
Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa that has been extensively researched over many years but as yet the mechanisms of pathogenesis are still not fully understood. Whilst the specific aetiological factors driving OLP remain ambiguous, evidence points to the development of a chronic, dysregulated immune response to OLP-mediating antigens presented by innate immune cells and oral keratinocytes leading to increased cytokine, chemokine and adhesion molecule expression. These molecules recruit T cells and mast cells to the diseased site and orchestrate a complex interplay between cells that culminates in keratinocyte cell death, mucosal basement membrane destruction and long-term chronicity of the disease. The main lymphocytes involved are thought to be CD8+ cytotoxic and CD4+ Th1 polarised T cells although recent evidence indicates the involvement of other Th subsets such as Th9, Th17 and Tregs, suggesting that a more complex immune cell relationship exists during the disease process. This review provides an overview of the immune mechanisms at play in OLP pathogenesis with particular emphasis on the role of the different Th subsets and how these recent discoveries may guide research towards identifying potential therapeutic targets.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 Wiley Periodicals LLC. This is an author-produced version of a paper subsequently published in Oral Diseases. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Oral lichen planus; Oral disease; T-cell; Mast cell; Antigen presenting cell; Keratinocyte |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 26 Jan 2022 10:45 |
Last Modified: | 28 Jun 2024 08:28 |
Status: | Published |
Publisher: | John Wiley & Sons Ltd |
Refereed: | Yes |
Identification Number: | 10.1111/odi.14142 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:182662 |