Danby, S.G. orcid.org/0000-0001-7363-140X, Andrew, P.V., Kay, L.J. et al. (5 more authors) (2022) Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema‐prone, skin. British Journal of Dermatology, 186 (5). pp. 875-886. ISSN 0007-0963
Abstract
Background
The skin of atopic dermatitis (AD) patients is characterised by abnormal stratum corneum (SC) lipid levels. Consequently, the lamellar matrices are disrupted and skin barrier function is diminished, increasing skin sensitivity to irritants and allergens.
Objective
To determine whether a cream containing ceramides, triglycerides and cholesterol in a multi-vesicular emulsion can reinforce the skin barrier, and protect against skin irritation.
Methods
A randomized observer-blind intrasubject-controlled study in 34 adults with dry, eczema-prone, skin was conducted. Each participant underwent 4 weeks treatment with the test cream on one forearm and lower leg and a reference emollient cream on the other. Skin properties were determined before and after treatment. Lipid structure was assessed by FTIR spectroscopy using a novel interface.
Results
Skin barrier integrity was greater at sites treated with the Test cream (effect size -161.9 area-under-the-TEWL-curve, 95% CI -205.5, -118.3), and skin sensitivity to sodium lauryl sulfate reduced (-0.5 points [97.57% CI -1.00, -0.25] visual redness and -15.34 g/m2/h [95% CI -20.28, -10.40] TEWL) compared to the reference. Sites treated with the test cream displayed enhanced lipid chain ordering, which was significantly associated with skin barrier integrity (r0.606). Compared to the reference, treatment with the Test cream increased hydration (8.61 capacitance units, 95% CI 6.61 to 10.60) and decreased signs of dryness.
Conclusion
The Test cream facilitates skin barrier restoration and protects the skin from dryness and irritation. Compared to a commonly prescribed emollient in the UK, the Test cream is highly suited to the management of dry, sensitive, skin.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number L'OREAL (U.K.) LIMITED NONE |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Dec 2021 13:08 |
Last Modified: | 24 Feb 2023 09:53 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/bjd.20955 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:181785 |