Zhang, M., Zhang, Y., Zhao, A. orcid.org/0000-0002-4626-9377 et al. (2 more authors) (2020) Towards data-driven modelling of SUMOylation following heat shock. In: Proceedings of 2020 7th International Conference on Biomedical and Bioinformatics Engineering. ICBBE '20: 2020 7th International Conference on Biomedical and Bioinformatics Engineering, 06-09 Nov 2020, Kyoto, Japan. Association for Computing Machinery , pp. 16-21. ISBN 9781450388221
Abstract
Understanding how cell fate is determined when exposed to extreme stresses such as heat shock is critical in biomedical systems. It has long been understood that exposure of cells to high temperature typically protect themselves with a heat shock response (HSR), where accumulation of denatured or unfolded proteins triggers the synthesis of heat shock proteins (HSPs) through the heat shock transcription factor, e.g., heat shock factor 1 (HSF1). Recent experimental work has also shown that protein posttranslational modifications (PTMs) such as SUMOylation play crucial roles in cellular responses to heat shock. As a complementary approach to the current experimental methodologies, in this study we aim to develop a mathematical model of SUMOylation-development synergism of HSR for the purpose of studying the dynamical behaviour of HSR quantitatively. The structure of our dynamical model is derived mostly from mass action kinetics while the model parameters are optimized by using a genetic algorithm (GA) based data-driven approach. The preliminary results show GA based data-driven approach has potentials for our modelling purpose.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Association for Computing Machinery. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Automatic Control and Systems Engineering (Sheffield) The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 15 Dec 2021 16:23 |
Last Modified: | 15 Dec 2021 16:23 |
Status: | Published |
Publisher: | Association for Computing Machinery |
Refereed: | Yes |
Identification Number: | 10.1145/3444884.3444888 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:181607 |