Li, X, Huo, J, Liu, Z et al. (5 more authors) (2019) An updated weight of evidence approach for deriving a health-based guidance value for 4-nonylphenol. Journal of Applied Toxicology, 39 (1). pp. 87-100. ISSN 0260-437X
Abstract
4-Nonylphenol (NP) is a persistent estrogen-active compound. Human exposure to NP is primarily through water and food. Although risk assessments of NP have been conducted by the European Union and a few other countries, only the Danish Veterinary and Food Administration, in 2000, proposed a tolerable daily intake of 0.005 mg kg−1 body weight (bw) day−1. New data have been accumulated since then, prompting an update on the risk assessment of NP. A weight of evidence approach is recommended for use in scientific assessments by several agencies, e.g., European Food Safety Authority, etc. Based on the results of a weight of evidence approach, two methods were used to derive the health-based guidance value (HBGV) for NP in this study, namely a no observed adverse effects level/lowest observable adverse effect level method, and a benchmark dose method. Considering the considerable uncertainty of benchmark dose model fitting of the available data, a tolerable daily intake value of 0.025 mg kg−1 bw day−1 was derived as a provisional HBGV for NP based on the lowest observable adverse effect level value of 15 mg kg−1 bw day−1 of the renal toxicity in rats, together with the uncertainty factor of 600. However, the HBGV of NP still needs further investigation.
Metadata
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Keywords: | 4-nonylphenol; hazard assessment; health-based guidance value (HBGV); tolerable daily intake (TDI); weight of evidence | ||||||||
Dates: |
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Institution: | The University of Leeds | ||||||||
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) | ||||||||
Funding Information: |
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Depositing User: | Symplectic Publications | ||||||||
Date Deposited: | 04 Nov 2021 11:26 | ||||||||
Last Modified: | 04 Nov 2021 11:26 | ||||||||
Status: | Published | ||||||||
Publisher: | Wiley | ||||||||
Identification Number: | https://doi.org/10.1002/jat.3661 | ||||||||
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